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The pathogenesis and pathophysiology of patients with functional gastrointestinal disorders remains incompletely understood. During the last years, the role of intestinal microbiota in the development of functional gut problems has received great interest, with a steadily increasing numbers of research projects assessing this. The role of this working team was to critically review the existing literature on the role of gut microbiota in functional GI disorders (FGIDs), with focus on clinical and translational aspects. Based on the literature search, we provided recommendations on how to implement the current knowledge into clinical practice, in order to improve the health of our patients.


Microbiota in Functional Bowel Disorders: a Rome Foundation Report
Simren, M., Barbara, G., Flint, H. J., Spiegel, B. M., Spiller, R. C., Vanner, S., Verdu, E. Zoetendal, E., Whorwell, P.
(2013). Gut, 62(1), 159-176.

Members of the Working Team


Magnus Simrén, MD, PhD
Department of Internal Medicine
Institute of Medicine
Sahlgrenska Academy
University of Gothenburg,
Gothenburg, Sweden


Giovanni Barbara, MD
Department of Medical and Surgical Sciences
Center for Applied Biomedical Research
University of Bologna
Bologna, Italy

Harry J Flint, BsC, PhD
Microbial Ecology Group
Rowett Institute of Nutrition and Health
University of Aberdeen
Bucksburn, Aberdeen, UK

Brennan M R Spiegel, MD, MSHS
VA Greater Los Angeles Healthcare System
David Geffen School of Medicine at UCLA
Los Angeles, USA

Robin C Spiller, MD, MsCNIHR Biomedical Research Unit
Nottingham Digestive Diseases Centre
University Hospital
Nottingham, UK

Stephen Vanner, MD
Gastrointestinal Diseases Research Unit
Queen’s University
Kingston, Ontario, Canada

Elena F Verdu, MD, PhD
Farncombe Family Digestive Health Research Institute
McMaster University
Hamilton, Canada

Peter J Whorwell, MD
Department of Medicine
University of Manchester
Wythenshawe Hospital
Manchester, UK

Erwin G Zoetendal, PhD
Laboratory of Microbiology
Department of Agrotechnology and Food Sciences
Wageningen University

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