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About

Central neuromodulators (antidepressants, antipsychotics, and other central nervous system targeted medications) are increasingly used for treatment of functional gastrointestinal disorders (FGIDs), now recognized as disorders of gut-brain interaction (DGBIs). However, the available evidence and guidance for the use of central neuromodulators in these conditions is scanty and incomplete. In this Rome Foundation Working Team report, a multidisciplinary team summarized available research evidence and clinical experience to provide guidance and treatment recommendations. Based on systematic and selectively focused review and the consensus of a multidisciplinary panel, we have provided summary information and guidelines for the use of central neuromodulators in the treatment of chronic gastrointestinal symptoms and DGBIs.

Publication

Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report
Drossman, D. A., Tack, J., Ford, A. C., Szigethy, E., Törnblom, H., & Van Oudenhove, L.
Gastroenterology, 154(4), 1140-1171.e1141.
Abstract

Members of the Working Team

Chair

Douglas A. Drossman, MD
Center for Functional Gastrointestinal and Motility Disorders
University of North Carolina
Chapel Hill, North Carolina

Center for Education and Practice of Biopsychosocial Care and Drossman Gastroenterology
Chapel Hill, North Carolina

Co-Chair
Jan Tack, MD, PhD
Jan Tack, MD, PhD
Translational Research Center for Gastrointestinal Disorders
University of Leuven
Leuven, Belgium

Alexander C. Ford, MBChB, MD, FRCP
Leeds Institute of Biomedical and Clinical Sciences
University of Leeds
Leeds, United Kingdom

Eva Szigethy, MD, PhD
Departments of Psychiatry and Medicine
University of Pittsburgh
Pittsburgh, Pennsylvania

Hans Törnblom, MD, PhD
Departments of Internal Medicine and Clinical Nutrition
Institute of Medicine
Sahlgrenska Academy, University of Gothenburg
Gothenburg, Sweden

Lukas Van Oudenhove, MD, PhD
Laboratory for Brain-Gut Axis Studies
Translational Research Center for Gastrointestinal Disorders
University of Leuven
Leuven, Belgium

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