Resources for research in DGBI
Publications relating to study design of diet, nutrition and/or DGBI studies
The following publications provide recommendations on best research practice in studies involving diet and/or DGBI.
| Nutrients, foods and diets trial design | Link to journal website |
|---|---|
| Staudacher HM, Yao CK, Chey WD, Whelan K. Optimal Design of Clinical Trials of Dietary Interventions in Disorders of Gut-Brain Interaction. Am J Gastroenterol. 2022; 117(6): 973-984. | https://journals.lww.com/ajg/fulltext/2022/06000/optimal_design_of_clinical_trials_of_dietary.30.aspx |
| Staudacher HM, Irving PM, Lomer MCE, Whelan K. The challenges of control groups, placebos and blinding in clinical trials of dietary interventions. Proc Nutr Soc. 2017; 76(3): 203-212. | https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/challenges-of-control-groups-placebos-and-blinding-in-clinical-trials-of-dietary-interventions/CD0D06FBF583C0E1DE908002A4133335 |
| Yao CK, Gibson PR, Shepherd SJ. Design of clinical trials evaluating dietary interventions in patients with functional gastrointestinal disorders. Am J Gastroenterol. 2013; 108(5): 748-58. | https://journals.lww.com/ajg/abstract/2013/05000/design_of_clinical_trials_evaluating_dietary.18.aspx |
| Tien DS, Hockey M, So D, Stanford J, Clarke ED, Collins CE, Staudacher HM. Recommendations for Designing, Conducting, and Reporting Feeding Trials in Nutrition Research. Adv Nutr. 2024; 15(10): 100283. | https://www.sciencedirect.com/science/article/pii/S2161831324001170 |
| Hohenschurz-Scmidt et al. Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies: the CoPPS Statement. BMJ. 2023; 381: e072108 | https://www.bmj.com/content/381/bmj-2022-072108 |
| Microbiome, probiotic and prebiotic trial design | |
|---|---|
| Warmbrunn MV, Attaye I, Herrema H, Nieuwdorp M. Protocol Standardization of Microbiome Studies—Daunting but Necessary. Gastroenterology. 2022; 162(7): 1822-1824. | https://www.gastrojournal.org/article/S0016-5085(22)00268-2/fulltext |
| Swann JR, et al. Considerations for the design and conduct of human gut microbiota intervention studies relating to foods. European Journal of Nutrition. 2020; 59:3347–3368. | https://link.springer.com/article/10.1007/s00394-020-02232-1 |
| Whelan, K., Alexander, M., Gaiani, C. et al. Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome. Nat Microbiol 2024; 9, 2785–2794. | https://www.nature.com/articles/s41564-024-01831-6 |
| Duncanson K et al. Diet-microbiota associations in gastrointestinal research: a systematic review. Gut Microbes. 2024;16(1):2350785 | https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2350785 |
| Shanahan ER, McMaster JJ, Staudacher HM. Conducting research on diet-microbiome interactions: A review of current challenges, essential methodological principles, and recommendations for best practice in study design. J Hum Nutr Diet. 2021; 34(4): 631-644. | https://onlinelibrary.wiley.com/doi/10.1111/jhn.12868 |
| Measuring mechanisms and endpoints in diet and nutrition studies in DGBI | |
|---|---|
| Biesiekierski JR, Yao C, Tuck C, Snelson M. Methodological advances in gastrointestinal tract physiology measurements: relevance to nutritional studies. Proceedings of the Nutrition Society. Published online 2024:1-36. | https://www.cambridge.org/core/journals/proceedings-of-the-nutrition-society/article/methodological-advances-in-gastrointestinal-tract-physiology-measurements-relevance-to-nutritional-studies/69902C0CAE8A113C5879FCC0ADD39DB2 |
| Nybacka, S., Störsrud, S., Liljebo, T., Le Nevé, B., Törnblom, H., Simrén, M., & Winkvist, A. (2019). Within-and between-subject variation in dietary intake of fermentable oligo-, di-, monosaccharides, and polyols among patients with irritable bowel syndrome. Current developments in nutrition, 3(2), nzy101. | https://www.sciencedirect.com/science/article/pii/S2475299122129896 |
| Shim, Jee-Seon, Kyungwon Oh, and Hyeon Chang Kim. "Dietary assessment methods in epidemiologic studies." Epidemiology and health 36 (2014). | https://e-epih.org/journal/view.php?doi=10.4178/epih/e2014009 |
| Thompson, Frances E., and Amy F. Subar. "Dietary assessment methodology." Nutrition in the Prevention and Treatment of Disease (2017): 5-48. | https://epi.grants.cancer.gov/dietary-assessment/Chapter%201_Coulston.pdf |
| Cuparencu, C., Bulmuş-Tüccar, T., Stanstrup, J. et al. Towards nutrition with precision: unlocking biomarkers as dietary assessment tools. Nat Metab 6, 1438–1453 (2024). | https://doi.org/10.1038/s42255-024-01067-y |