Assistant Professor of Medicine at Western University and Medical Director of the Gastrointestinal Motility program at St. Joseph’s Health Care.

Keith McIntosh, MD

Title: “FODMAPS alter symptoms and the metabolome of patients with IBS: A randomized controlled trial.”

Gut 2017; 66:1241-1251

This article was cited 65 times.

This study looked to gain mechanistic insights and compared effects of low FODMAP and high FODMAP diets on symptoms, the metabolome and the microbiome of patients with IBS. In acontrolled, single blind study of patients with IBS (Rome III criteria) randomised to a low (n=20) or high (n=20) FODMAP diet for 3 weeks, symptoms were assessed using the IBS symptom severity scoring (IBS-SSS). The metabolome was evaluated using the lactulose breath test (LBT) and metabolic profiling in urine using mass spectrometry. Stool microbiota composition was analysed by 16S rRNA gene profiling. The article concluded that IBS symptoms are linked to FODMAP content and associated with alterations in the metabolome. In subsets of patients, FODMAPs modulate histamine levels and the microbiota, both of which could alter symptoms.

Ken Heaton Award Recipients

2019 Award for Most Cited Paper – Keith McIntosh, MD

2018 Award for Most Cited Paper – Doris Vandeputte, PhD

2017 Award for Most Cited Paper – Giada De Palma

2016 Award for Most Cited Paper – Emma Halmos

2015 Award for Most Cited Paper – Jessica R. Biesiekierski

2014 Award for Most Cited Paper – Madhusudan Grover

2014 Award for Most Cited Paper – Natasha Koloski

2013 Award for Most Cited Paper – Jessica R. Biesiekierski

2012 Award for Most Cited Paper – Ted J. Kaptchuck and Anthony J. Lembo

2011 Award for Most Cited Paper – S.M. O’Mahony